Title of project:
Blebbing on Oscillating Surfaces
Code:
TW2122B
Supervisor:
Dr. Thomas E. Woolley
Project description:
We propose to construct a mechanical model of muscle stem cell motion combining solid mechanics, stochastic theory and numerical simulations. During healing muscle stem cells adopt an amoeboid form of translocation, known as blebbing, in which cells are round and display highly dynamic plasma membrane extensions and retractions. The model will be a novel testing bed for biological hypotheses of cellular motion and illuminate connections between the multiple scales, as well as provide new mathematical insights into the connection between motion and surface geometry.
The aim is to model this mechanism of cellular motion and characterize the relationship between cell movement and the surrounding environmental geometry e.g. size, shape and topology. This relationship is usually discounted in experiments as extracted cells are placed on flat plates, or gels, which do not match the complicated heterogeneous environments that cells would have to naturally contend with. Mathematical modelling provides us with a way to test these disregarded factors and challenge current biological knowledge as to their importance.
Project offered as double module, single module, or both:
Double
Number of students who can be supervised on this project:
1